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Treatment with 40 mg of Pantoprazole produced significantly greater increases in gastric pH than the 20 mg dose.

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In a clinical pharmacology study, Pantoprazole 40 mg given once daily for 2 weeks had no effect on the levels of the following hormones: cortisol, testosterone, triiodothyronine (T 3), thyroxine (T 4), thyroid-stimulating hormone (TSH), thyronine-binding protein, parathyroid hormone, insulin, glucagon, renin, aldosterone, follicle-stimulating hormone, luteinizing hormone, prolactin, and growth hormone.

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Ongoing reflux of non-acid and acid material may occur during transient lower esophageal sphincter relaxations (TLESRs) and novel agents that target this motor pattern may be able to reduce symptoms.

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Conclusions: as a result of the damage due to chronic gastroesoptmgeal reflux, pts can develop esophagitis or Barrett's esophagus.

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Pantoprazole versus lansoprazole in patients with reflux esophagitis.

Pantoprazole sodium For Delayed-Release Oral Suspension, 40 mg, contains the active ingredient pantoprazole sodium sesquihydrate in the form of enteric-coated granules in unit dose packets.

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Pantoprazole Sodium Delayed-Release Tablets were used in the following clinical trials.

Because these pediatric trials had no placebo, active comparator, or evidence of a dose response, the trials were inconclusive regarding the clinical benefit of PROTONIX for symptomatic GERD in the pediatric population.

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Peak serum concentration (C max) and area under the serum concentration time curve (AUC) increase in a manner proportional to oral and intravenous doses from 10 mg to 80 mg.

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