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Reductions in the dosage of L-dopa were also allowed if patients experienced adverse events that the investigator considered related to dopaminergic therapy.
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The authors discuss alternative treatment strategies for Parkinson's disease and medications that may help control ICDs, such as antidepressants, atypical antipsychotics and antiepileptic drugs.
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In a placebo-controlled clinical trial, hallucination occurred in 0 of 43 patients taking entacapone plus L-dopa, in 9 of 155 patients taking REQUIP XL (ropinirole extended release tablets) plus L-dopa (6%), and in 7 of 47 patients taking entacapone with REQUIP XL (ropinirole extended release tablets) plus L-dopa (15%).
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TREAT RLS 1 study was the TREAT RLS 2 study conducted by Walters and colleagues ().
My heart is racing and I am more anxious until the dosage wears off.
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Table 5 lists treatment-emergent adverse reactions that occurred in at least 2% of patients with RLS treated with REQUIP participating in the 12-week, double-blind, placebo-controlled trials and were numerically more common than the incidence for placebo-treated patients.
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